Simply put this manga is amazing and aside from a few pretty inconsequential problems I had with it this is gonna be nothing but praise.

At the core Ashita no Joe is a character driven drama about Joe himself, people around him and they they go through their difficult lives. As such I don't you can't talk about story without talking about characters and you can't talk much about characters without spoiling manga.
What I can say though is that impressive how much nuance the main cast has. Aside from some supporting characters that don't play a large part in the story everyone has a very believable multifaceted personality and over the course of their arc you learn about who they are, how they act and how they change as well as what causes it. It's a long, difficult and a very tragic story in a way that's not immediately obvious or rather it's never thrown in your face. It's practically overwhelming how much there is to say about Joe's and his passion to fight until he burns up his youth, Tange who relives his former glory by guiding Joe to success while trying to contain his self-destructive habits, Yoko's subtle attempts to straight out Joe's character or special bonds shared between Joe and most of his opponents. The manga is brimming with countless interesting and intricate character moments. Because of this it can be slow at times which is one of the minor problems I had when reading it but what it gives you in return is so satisfying that it's hard to complain about.
It's probably a disservice to talk so little about this aspect of Ashita no Joe for how strong and prevalent it is but I feel like going into more detail would just turn into plot recap or character analysis.

As far as complaints go I have only one that in any way affected my enjoyment which is Harimau, from now on it's gonna be spoilers so if you haven't read the manga skip this paragraph. I know why Harimau was part of the story, I know his purpose and as far as that goes he served it well but reading 19th volume was hard at times just because of how ridiculous he is. Most of the manga is fairly down the earth, there's little exaggeration when it comes to abilities of the boxers and no any real melodrama but then comes along a tribal boxer found in the jungles who was raised by animals and could kill anything in the jungles by the age of 12. Some time later by random chance he's discovered by an english explorer and taught how to box however it's later revealed his boxing is lackluster and he only wins thanks to being wild, strong and tough. This could've been more or less fine if he was just kind of dumb but strong and aggressive slugger that forces Joe to revert to his old self but the guy is literally acting like an animal which Joe notes in one of the panels. Not only his character is fucking absurd his fighting style is not any better. The man jumps from rope to rope like a kangaroo delivering strong punches and his other signature attacks are jumping above someone's head and hitting them midair or doing a fucking double backflip while uppercutting his opponent each spin. It's dumb and I could've bring myself to like any of that.

That concludes the story part. What remains is art and I loved that too. I'm usually not too keen on most very old manga/anime because of seemingly common overall unimpressive simplicity and very cartoonish designs which can ruin any scene with serious tone, but I feel like AnJ hits the sweet spot. There's plenty of detail in backgrounds, occasional spreads as well as bodies and faces while still mostly cartoonish are not comically exaggerated save for a few examples and can covey a large array of emotion, sometimes even fairly subtle ones.

Overall it's a great manga that's very much worth a read, especially if you're into having well written characters.